Fragment-based drug design (FBDD) has led to a revolution in contemporary drug discovery, facilitating a bottom-up approach to the identification and evolution of bioactive small molecules into viable ...

Since the successful production of humanized antibodies in the 1980s, antibody-based medications have become increasingly essential in clinical treatment, taking advantage of their low immunogenicity ...

Developing new pharmaceuticals is a complex and costly process that requires innovation and efficiency. High-throughput immunoassays (HTIs) are an emerging technology poised to accelerate the drug ...

To battle this epidemic, the National Institutes of Health (NIH) launched the Helping to End Addiction Long-term (HEAL) Initiative in 2018. As part of this effort, scientists at the NIH National ...

The Echo® MS+ system unlocks enhanced high-throughput screening capability by bringing acoustic ejection mass spectrometry (AEMS) approaches to the SCIEX ZenoTOF 7600 system. FRAMINGHAM, ...

Discovering effective drug combinations may now be easier thanks to a screening platform made public today by St. Jude ...

Physiochemical properties such as solubility and dissolution rate play a crucial role when it comes to the therapeutic efficacy of oral drug formulations. According to the Biopharmaceutical ...

Live-cell imaging, integrated with AI/ML, enhances phenotypic screening, improving drug discovery and lead optimization. European companies are pioneering live-cell imaging technologies, advancing in ...

This rapid screening process identified an iridium-based antibiotic candidate that shows promise in human cells to kill bacteria while remaining nontoxic.