The spliceosome is best known for shepherding primary messenger RNA transcripts to maturity. This enzyme complex also contributes to the synthesis of an enzyme that maintains chromosome ends. Indeed, ...
In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...
To sustain life, processes in biological cells have to be strictly controlled both in time and in space. Researchers have elucidated a previously unknown mechanism that regulates one of the essential ...
In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...
Researchers at the Centre for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine inside every cell. The ...
A conserved region of U6 small nuclear RNA has been implicated in binding an essential metal ion. Is this a glimpse of the spliceosome's catalytic core? Identifying divalent metal ion binding sites in ...
This is a preview. Log in through your library . Abstract Recently, it has been reported that there is a differential subcellular distribution of components of the minor U12-dependent and major ...
After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...
Ke Wang, Changping Yin, Xian Du, Suli Chen, Jianshu Wang, Li Zhang, Lantian Wang, Yong Yu, Binkai Chi, Min Shi, Changshou Wang, Robin Reed, Yu Zhou, Jing Huang, Hong Cheng Proceedings of the National ...
From neurosurgery to bar code readers, lasers have been used in a myriad of applications since they were first introduced in the late 1950’s. Now, with the work being done in Jeff Gelles’ Lab at ...
Schizophrenia affects around 200,000 people in the United States, and millions more worldwide; it can be a very serious disease. Little is known, however, about the mechanisms that underlie the ...
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