The various identities of cells, whether they are in the brain, heart, kidney, or any other tissue, are defined by the genes they expressed. In basic terms, the genes that are active in a cell are ...

Figure 2: Cbr1 is the major Dph3 reductase in vivo. In summary, we identified Cbr1 as the major physiological reductase of Dph3, the electron carrier for the radical SAM enzymes required for two ...

Figure 1: Identification and determination of the chemical structure of the new modified nucleoside in archaeal tRNA Ile2. Figure 2: Agmatine is a metabolic substrate of agm 2 C in archaeal cells.

Modification of certain tRNA molecules at the wobble position regulates selective mRNA translation and impact on protein expression. The GIGA-ULiège team discovered that melanoma that carry the BRAF ...

Mayumi Yoshida, Naoyuki Kataoka, Kenjyo Miyauchi, Kenji Ohe, Kei Iida, Suguru Yoshida, Takayuki Nojima, Yukiko Okuno, Hiroshi Onogi, Tomomi Usui, Akihide Takeuchi, Takamitsu Hosoya, Tsutomu Suzuki, ...

A recent finding by a North Carolina State University biochemist advances the fundamental biology of how genetic information, encoded in DNA, is decoded for the production of proteins. A recent ...

A recent finding by a North Carolina State University biochemist advances the fundamental biology of how genetic information, encoded in DNA, is decoded for the production of proteins. Dr. Paul F.

When proteins are produced in cells based on the "genetic code" of codons, there is a precise process under which molecules called transfer RNA (tRNA) bind to specific amino acids and then transport ...

The principle behind the chemical modification of 'transfer RNA' (tRNA), which is involved in the synthesis of proteins, a core component of life, has been elucidated. The co-crystal structure of ...

Researchers have revealed that malignant melanoma can reprogram their protein synthesis machinery and become addicted to a new family of enzymes that modify transfer RNAs during acquired resistance.

A team of researchers led by Dr Pierre Close, WELBIO researcher at the ULiège GIGA Institute and Dr Francesca Rapino has uncovered a new therapeutic opportunity in the treatment of malignant melanoma ...