ALDH2 is a tetrameric enzyme that contains three domains; two dinucleotide-binding domains and a three-stranded beta-sheet domain. The active site of ALDH2 is divided into two halves by the …

Nov 13, 2025 · ALDH2 (Aldehyde Dehydrogenase 2 Family Member) is a Protein Coding gene. Diseases associated with ALDH2 include Alcohol Sensitivity, Acute and Amed Syndrome, Digenic. …

Aug 2, 2025 · ALDH2 is a member of the aldehyde dehydrogenase family of enzymes. Its primary function involves breaking down harmful aldehydes into less toxic substances. Specifically, ALDH2 is …

ALDH2 is an ALDH family member that catalyzes the oxidation of various aldehydes; it is widely distributed throughout the body as an oxidoreductase, but is mainly found in the liver, heart, lungs, …

Feb 13, 2023 · Aldehyde dehydrogenase 2 (ALDH2), a key enzyme for the detoxification of alcohol-derived acetaldehyde, has been implicated in the pathogenesis of various types of cardiovascular …

Oct 4, 2024 · Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme primarily involved in the detoxification of alcohol-derived aldehyde and endogenous toxic aldehydes.

ALDH2 refers to a specific isozyme of aldehyde dehydrogenase that metabolizes acetaldehyde into acetic acid and is characterized by a known polymorphism (ALDH2*2) associated with decreased …

Apr 29, 2025 · Explore the cellular role of ALDH2, the genetic basis of its deficiency, and its metabolic and clinical implications for health and disease management.

Using an unbiased proteomic search, Chen et al. (2008) identified mitochondrial ALDH2 as an enzyme whose activation correlated with reduced ischemic heart damage in rodent models.

ALDH1 and ALDH2 are the most important enzymes for aldehyde oxidation, and both are tetrameric enzymes composed of 54 kDa subunits. These enzymes are found in many tissues of the body but …